Florence is the main setting of Leonardo. A beautiful city, it is currently ruled by Duke Rocco de Medici after Rocco's father, the previous Duke of Florence was murdered by Piero de Medici. It has been saved from a war with Milan while it acts as the home to many good people including Leonardo da Vinci, Lisa Gherardini, Niccolo Machiavelli and Lorenzo de Medici.

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